Dependence of the rate of stress-induced ulcers on acidity of gastric juice in the post-surgery period in children

Abstract

Objective: to analyse the dependence of stress-induced erosive and ulcerous changes of the gastrointestinal mucosa (GIMCs) in the post-surgery period on the acidity level of gastric juice.
Material and methods. In children with surgical pathology in the pre-surgery period and in 3 days after the operation, fibroesophagogastroduodenoscopy was performed using the Olimpus Evis Lucera CLV-260SL apparatus (Olimpus, Japan); the acidity of the intragastric contents was determined by using the acidogastrograph АГ-1рН-М (manufactured by Start LLC, Ukraine), which was provided during the endoscopic studies and intraoperative express monitoring.
Results. GIMCs were detected in 25 children in the post-surgery period that made up 33.3% of all examined patients. The dynamics of intragastric pH was as follows: mean pH for all patients – 4.09; mean pH for the patients with GIMCs – 3.48; mean pH for the patients without manifestations of GIMCs – 4.35. The gastric juice pH value during the intraoperative monitoring in patients with manifestations of GIMCs in the post-surgery period was on average 2.05+/-0.23 (р=0.0001), while in patients without the postoperative GI complications – 3.42+/-0.97 (р=0.0001).
Conclusions. The GIMCs rate in the post-surgery period in children is 33.3%, which determines the relevance of the chosen direction of the research. A significant factor in the formation of stress ulcers and erosions is also the acidity of gastric juice with a tendency to lower pH values in patients with GIMCs.