Surgical treatment of hepatoblastoma

Authors

  • O. G. Kotenko Shalimov National Institute of Surgery and Transplantology, Kyiv, Ukraine, Ukraine
  • M. S. Grygorian Shalimov National Institute of Surgery and Transplantology, Kyiv, Ukraine, Ukraine
  • O. V. Grynenko Shalimov National Institute of Surgery and Transplantology, Kyiv, Ukraine, Ukraine
  • A. V. Gusev Shalimov National Institute of Surgery and Transplantology, Kyiv, Ukraine, Ukraine
  • O. O. Korshak Shalimov National Institute of Surgery and Transplantology, Kyiv, Ukraine, Ukraine
  • O. M. Ostapyshen Shalimov National Institute of Surgery and Transplantology, Kyiv, Ukraine, Ukraine
  • O. O. Popov Shalimov National Institute of Surgery and Transplantology, Kyiv, Ukraine, Ukraine
  • D. O. Fedorov Shalimov National Institute of Surgery and Transplantology, Kyiv, Ukraine, Ukraine

DOI:

https://doi.org/10.15574/PS.2019.63.29

Keywords:

hepatoblastoma, children, liver resection, liver transplantation

Abstract

Objective. To study and improve the results of surgical treatment of children with hepatoblastoma.

Materials and methods. The experience of surgical treatment of 90 children with hepatoblastoma is presented: 81 patients who underwent liver resection,

and in 9 cases with a nonresectable hepatoblastoma a living-donor liver transplantation was performed.

Results. More severe postoperative complications (from ІІІ-b to V degree according to Dindo–Clavien) were observed in the resection group of patients. Postoperative mortality after liver resection was 5% (n=4), and there were no lethal cases after liver transplantation. The 5-year relapse-free survival rate in the transplant group was 69.2% versus 62.5% in the resection group, and the overall survival rate was 75% versus 71%, respectively.

Conclusions. Resection and transplantation technologies are effective methods of surgical treatment of hepatoblastoma in children, and in combination with chemotherapy, they can produce a good long-term results. The immediate and long-term results after liver transplantation are better than after liver resection, even though transplantation group patients have a larger tumor lesion in the liver. Liver transplantation is a good treatment option for children with unresectable hepatoblastoma.

References

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Issue

No. 2(63) (2019): Paediatric surgery. Ukraine

Section

Original articles. Abdominal surgery

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