Infantile hemangioma
DOI:
https://doi.org/10.15574/PS.2020.68.49Keywords:
infantile hemangioma, diagnostic, treatmentAbstract
Infantile hemangioma is one of the most common benign vascular malformations in children. Besides that, some questions about classification, diagnostic, and choice of method of treatment remains the questionable. The modern data about classification, clinical course, diagnostic, and main principles of treatment of infantile hemangioma are presented in this work. In most cases, the uncomplicated clinical course of infantile hemangioma was observed. However, in some patients the complications may arise. Ulceration, obstruction, functional impairment, and disfigurement are the most often complications of infantile hemangioma. Although, most infantile hemangiomas tend to regress spontaneously, some of them required the treatment. Applying of the β-blockers (systemic or topical), laser therapy, and surgery are the main methods that used for the treatment of infantile hemangiomas. Patients with infantile hemangiomas, despite the simplicity of diagnostic, should be treated on specialized centers. Early detection of at-risk infantile haemangioma is a major point, requiring an increased awareness by paediatricians, with the aim to prevent the complications development. However, it was proven the efficacy of propranolol treatment for the all types of infantile hemangiomas, the long-term follow-up studies are needed to assess its safety with regard to neurodevelopment.
References
Ábarzúa-Araya A, Navarrete-Dechent CP, Heusser F et al. (2014). Atenolol versus propranolol for the treatment of infantile hemangiomas: a randomized controlled study. J Am Acad Dermatol. 70 (6): 1045-1049. https://doi.org/10.1016/j.jaad.2014.01.905; PMid:24656727
Ahogo CK, Ezzedine K, Prey S et al. (2013). Factors associated with the relapse of infantile haemangiomas in children treated with oral propranolol. Br J Dermatol. 169 (6): 1252-1256. https://doi.org/10.1111/bjd.12432; PMid:23662995
Bauland CG, Lüning TH, Smit JM et al. (2011). Untreated hemangiomas: growth pattern and residual lesions. Plast Reconstr Surg. 127 (4): 1643-1648. https://doi.org/10.1097/PRS.0b013e318208d2ac; PMid:21460670
Bernabeu-Wittel J, Narváez-Moreno B, de la Torre-Garciá JM et al. (2015). Oral nadolol for children with infantile hemangiomas and sleep disturbances with oral propranolol. Pediatr Dermatol. 32 (6): 853-857. https://doi.org/10.1111/pde.12686; PMid:26447831
Bitar MA, Moukarbel RV, Zalzal GH. (2005). Management of congenital subglottic hemangioma: trends and success over the past 17 years. Otolaryngol Head Neck Surg. 132 (2): 226-231 https://doi.org/10.1016/j.otohns.2004.09.136; PMid:15692531
Brandling-Bennett HA, Metry DW, Baselga E et al. (2008). Infantile hemangiomas with unusually prolonged growth phase: a case series. Arch Dermatol. 144 (12): 1632-1637. https://doi.org/10.1001/archderm.144.12.1632; PMid:19075148
Castren E, Salminen P, Gissler M et al. (2016). Risk factors and morbidity of infantile haemangioma: preterm birth promotes ulceration. Acta Paediatr. 105 (8): 940-9455. https://doi.org/10.1111/apa.13460; PMid:27146410
Cazeau C, Blei F, Gonzáles Hermosa MDRF et al. (2017). Burden of infantile hemangioma on family: an international observational cross-sectional study. Pediatr Dermatol. 34 (3): 295-302. https://doi.org/10.1111/pde.13133; PMid:28382698
Chamlin SL, Haggstrom AN, Drolet BA et al. (2007). Multicenter prospective study of ulcerated hemangiomas. J Pediatr. 151 (6): 684-689. https://doi.org/10.1016/j.jpeds.2007.04.055; PMid:18035154
Chang L, Chen H, Yang X et al. (2018). Intralesional bleomycin injection for propranolol-resistant hemangiomas. J Craniofac Surg. 29 (2): e128-130. https://doi.org/10.1097/SCS.0000000000004152; PMid:29381619
Chang L, Ye X, Qiu Y et al. (2016). Is propranolol safe and effective for outpatient use for infantile hemangioma? A prospective study of 679 cases from one center in China. Ann Plast Surg. 76(5): 559-563. https://doi.org/10.1097/SAP.0000000000000506; PMid:26101993
Chen XD, Ma G, Chen H et al. (2013). Maternal and perinatal risk factors for infantile hemangioma: a case-control study. Pediatr Dermatol. 30 (4): 457-461. https://doi.org/10.1111/pde.12042; PMid:23278441
Chen ZY, Wang QN, Zhu YH et al. (2019). Progress in the treatment of infantile hemangioma. Ann Transl Med. 7 (22): 692. https://doi.org/10.21037/atm.2019.10.47; PMid:31930093 PMCid:PMC6944559
Cheng CE, Friedlander SF. (2016). Infantile hemangiomas, complications and treatments. Semin Cutan Med Surg. 35 (3):108-116. https://doi.org/10.12788/j.sder.2016.050; PMid:27607318
Chinnadurai S, Snyder K, Sathe N et al. (2016). Diagnosis and management of infantile hemangioma. Rockville (MD): Agency for Healthcare Research and Quality (US). Report No: 16-EHC002-EF.
Cho YK, Ryu DW, Chung HY et al. (2015). Surgical management of scalp infantile hemangiomas. J Craniofac Surg. 26 (4): 1169-1172. https://doi.org/10.1097/SCS.0000000000001561; PMid:26080151
Couto JA, Greene AK. (2014). Management of problematic infantile hemangioma using intralesional triamcinolone: efficacy and safety in 100 infants. J Plast Reconstr Aesthet Surg. 67 (11): 1469-1474. https://doi.org/10.1016/j.bjps.2014.07.009; PMid:25104131
Dai Y, Hou F, Buckmiller L et al. (2012). Decreased eNOS protein expression in involuting and propranolol-treated hemangiomas. Arch Otolaryngol Head Neck Surg. 138 (2): 177-182. https://doi.org/10.1001/archoto.2011.1096; PMid:22351865
Darrow DH, Greene AK, Mancini AJ, Nopper AJ, Section on Dermatology, Section on Otolaryngology-Head and Neck Surgery, and Section on Plastic Surgery. (2015). Diagnosis and management of infantile hemangioma. Pediatrics. 136 (4): e1060-1104. https://doi.org/10.1542/peds.2015-2485; PMid:26416931
Darrow DH, Greene AK, Mancini AJ, Nopper AJ, Section on Dermatology, Section on Otolaryngology-Head and Neck Surgery, and Section on Plastic Surgery. (2015). Diagnosis and management of infantile hemangioma: executive summary. Pediatrics. 136 (4): 786-791. https://doi.org/10.1542/peds.2015-2482; PMid:26416928
Ding Y, Zhang JZ, Yu SR et al. (2020). Risk factors for infantile hemangioma: a meta-analysis. World J Pediatr. 16 (4): 377-384. https://doi.org/10.1007/s12519-019-00327-2; PMid:31853885
Drolet BA, Esterly NB, Frieden IJ. (1999). Hemangiomas in children. Engl J Med. 341 (3): 173-181. https://doi.org/10.1056/NEJM199907153410307; PMid:10403856
Drolet BA, Frommelt PC, Chamlin SL et al. (2013). Initiation and use of propranolol for infantile hemangioma: report of a consensus conference. Pediatrics. 131 (1): 128-140. https://doi.org/10.1542/peds.2012-1691; PMid:23266923 PMCid:PMC3529954
Düzenli Kar Y, Ozdemir ZC, Acu B, Bor O. (2019). Infantile hemangioma: efficacy of low-dose propranolol and of intralesional bleomycin injection for propranolol non-response. Pediatr Int. 61 (5): 459-464. https://doi.org/10.1111/ped.13830; PMid:30861274
FDA. (2014). HEMANGEOLTM (propranolol hydrochloride oral solution). Cited 2019 Sep 25. URL: https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/205410s000lbl.pdf.
Fuchsmann C, Quintal MC, Giguere C et al. (2011). Propranolol as first-line treatment of head and neck hemangiomas. Arch Otolaryngol Head Neck Surg. 137 (5): 471-478. https://doi.org/10.1001/archoto.2011.55; PMid:21576558
Gorincour G, Kokta V, Rypens F et al. (2005). Imaging characteristics of two subtypes of congenital hemangiomas: rapidly involuting congenital hemangiomas and non-involuting congenital hemangiomas. Pediatr Radiol. 35 (12): 1178-1185. https://doi.org/10.1007/s00247-005-1557-9; PMid:16078073
Haggstrom AN, Drolet BA, Baselga E et al. (2006). Prospective study of infantile hemangomas: clinical characteristics predicting complications and treatment. Pediatrics. 118 (3): 882-887. https://doi.org/10.1542/peds.2006-0413; PMid:16950977
Haggstrom AN, Drolet BA, Baselga E, Hemangioma Investigator Group et al. (2007). Prospective study of infantile hemangiomas: demographic, prenatal, and perinatal characteristics. J Pediatr. 150 (3): 291-294. https://doi.org/10.1016/j.jpeds.2006.12.003; PMid:17307549
Harter N, Mancini AJ. (2019). Diagnosis and management of infantile hemangiomas in the neonate. Pediatr Clin North Am. 66 (2): 437-459. https://doi.org/10.1016/j.pcl.2018.12.011; PMid:30819347
Hermans DJ, Boezeman JB, Van de Kerkhof PC et al. (2009). Differences between ulcerated and non-ulcerated hemangiomas, a retrospective study of 465 cases. Eur J Dermatol. 19 (2): 152-156. https://doi.org/10.1684/ejd.2008.0576; PMid:19106042
Hoeger PH, Harper JI, Baselga E et al. (2015). Treatment of infantile haemangiomas: recommendations of a European expert group. Eur J Pediatr. 174 (7): 855-865. https://doi.org/10.1007/s00431-015-2570-0; PMid:26021855
Hunjan MK, Schoch JJ, Anderson KR et al. (2017). Prenatal risk factors for infantile hemangioma development. J Invest Dermatol. 137 (4): 954-957. https://doi.org/10.1016/j.jid.2016.10.047; PMid:27940221 PMCid:PMC6309253
International Society for the Study of Vascular Anomalies. (2014). ISSVA classification of vascular anomalies. Accessed: April 2015. URL: issva.org/classification.
Itinteang T, Withers AH, Davis PF, Tan ST. (2014). Biology of infantile hemangioma. Front Surg. 1: 38. https://doi.org/10.3389/fsurg.2014.00038; PMid:25593962 PMCid:PMC4286974
Ji Y, Chen S, Xu C, Li L, Xiang B. (2015). The use of propranolol in the treatment of infantile haemangiomas: an update on potential mechanisms of action. Br J Dermatol. 172 (1): 24-32. https://doi.org/10.1111/bjd.13388; PMid:25196392
Kessels JP, Hamers ET, Ostertag JU. (2013). Superficial hemangioma: pulsed dye laser versus wait-and-see. Dermatol Surg. 39 3 Pt 1): 414-421. https://doi.org/10.1111/dsu.12081; PMid:23279058
Krowchuk DP, Frieden IJ, Mancini AJ et al. (2019). Clinical practice guideline for the management of infantile hemangiomas. Pediatrics. 143 (1): e20183475. https://doi.org/10.1542/peds.2018-3475; PMid:30584062
Léauté-Labrèze C, Dumas de la Roque E, Hubiche T et al. (2008). Propranolol for severe hemangiomas of infancy. N Engl J Med. 358 (24): 2649-2651. https://doi.org/10.1056/NEJMc0708819; PMid:18550886
Léauté-Labrèze C, Harper JI, Hoeger PH. (2017). Infantile haemangioma. Lancet. 390 (10089): 85-94. https://doi.org/10.1016/S0140-6736(16)00645-0
Léauté-Labrèze C, Hoeger PH, Mazereeuw-Hautier J et al. (2015). A randomized controlled trial of oral propranolol in infantile hemangioma. N Engl J Med. 372 (8): 735-746. https://doi.org/10.1056/NEJMoa1404710; PMid:25693013
Léauté-Labrèze C, Torres EB, Weibel L et al. (2020). The infantile hemangioma referral score: a validated tool for physicians. Pediatrics. 145 (4): e20191628. https://doi.org/10.1542/peds.2019-1628; PMid:32161112
Li H, Lou Y, Zhang R et al. (2019). Propranolol accelerats hemangioma stem cell transformation into adipocyte. Ann Plast Surg. 83 (5): e5-e13. https://doi.org/10.1097/SAP.0000000000002104; PMid:31609806
Liang MG, Frieden IJ. (2014). Infantile and congenital hemangiomas. Semin Pediatr Surg. 23 (4): 162-167. https://doi.org/10.1053/j.sempedsurg.2014.06.017; PMid:25241092
Lister W. (1938). The natural history of strawberry naevi. Lancet. 231 (5991): 1429-1434. https://doi.org/10.1016/S0140-6736(00)70042-0
Marqueling AL, Oza V, Frieden IJ, Puttgen KB. (2013). Propranolol and infantile hemangiomas four years later: a systematic review. Pediatr Dermatol. 30 (2): 182-191. https://doi.org/10.1111/pde.12089; PMid:23405852
Mawn LA. (2013). Infantile hemangioma: treatment with surgery or steroids. Am Orthopt J. 63: 6-13. https://doi.org/10.3368/aoj.63.1.6; PMid:24260801
Mulliken JB, Glowacki J. (1982). Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. Plast Reconstr Surg. 69 (3): 412-422. https://doi.org/10.1097/00006534-198203000-00002; PMid:7063565
Orlow SJ, Isakoff MS, Blei F. (1997). Increased risk of symptomatic hemangiomas of the airway in association with cutaneous hemangiomas in a «beard» distribution. J Pediatr. 131 (4): 643-646. https://doi.org/10.1016/S0022-3476(97)70079-9
Pan WK, Li P, Guo ZT, Huang Q, Gao Y. (2015). Propranolol induces regression of hemangioma cells via the down-regulation of the PI3K/Akt/eNOS/ VEGF pathway. Pediatr Blood Cancer. 62 (8): 1414-1420. https://doi.org/10.1002/pbc.25453; PMid:25728347
Pandey A, Gangopadhyay AN, Sharma SP et al. (2010). Evaluation of topical steroids in the treatment of superficial hemangioma. Skinmed. 8 (1): 9-11.
Patterson A. (1894). Spontaneous cure of a naevus maternus - large vascular tumor occupying side of neck. South Med Rec. 24: 477.
Püttgen K, Lucky A, Adams D, Hemangioma Investigator Group et al. (2016). Topical timolol maleate treatment of infantile hemangiomas. Pediatrics. 138 (3): e20160355. https://doi.org/10.1542/peds.2016-0355; PMid:27527799
Raphael MF, Breugem CC, Vlasveld FA et al. (2015). Is cardiovascular evaluation necessary prior to and during beta-blocker therapy for infantile hemangiomas? a cohort study. J Am Acad Dermatol. 72 (3): 465-472. https://doi.org/10.1016/j.jaad.2014.12.019; PMid:25592625
Reem RE, Golden RP. (2014). Periocular hemangiomas and lymphangiomas. Pediatr Clin North Am. 61 (3): 541-553. https://doi.org/10.1016/j.pcl.2014.03.007; PMid:24852151
Schwartz SR, Blei F, Ceisler E et al. (2006). Risk factors for amblyopia in children with capillary hemangiomas of the eyelids and orbit. J AAPOS. 10 (3): 262-2688. https://doi.org/10.1016/j.jaapos.2006.01.210; PMid:16814181
Shah SD, Baselga E, McCuaig C et al. (2016). Rebound growth of infantile hemangiomas after propranolol therapy. Pediatrics. 137(4): e20151754. https://doi.org/10.1542/peds.2015-1754; PMid:26952504
Sherrington CA, Sim DK, Freezer NJ, Robertson CF. (1997). Subglottic haemangioma. Arch Dis Child. 76 (5): 458-459. https://doi.org/10.1136/adc.76.5.458; PMid:9196368 PMCid:PMC1717188
Smith CJF, Friedlander SF, Guma M et al. (2017). Infantile hemangiomas: an updated review on risk factors, pathogenesis, and treatment. Birth Defects Res. 109 (11): 809-815. https://doi.org/10.1002/bdr2.1023; PMid:28402073 PMCid:PMC5839165
Soliman YS, Khachemoune A. (2018). Infantile hemangiomas: our current understanding and treatment options. Dermatol Online J. 24 (9): 13030/qt5jt8q9km.
Tan OT, Murray S, Kurban AK. (1989). Action spectrum of vascular specific injury using pulsed irradiation. J Invest Dermatol. 92 (6): 868-871. https://doi.org/10.1111/1523-1747.ep12696885; PMid:2723451
Tang LY, Hing JW, Tang JY et al. (2016). Predicting complications with pretreatment testing in infantile haemangioma treated with oral propranolol. Br J Ophthalmol. 100 (7): 902-906. https://doi.org/10.1136/bjophthalmol-2015-307284; PMid:26504177
Uthurriague C, Boccara O, Catteau B et al. (2016). Skin patterns associated with upper airway infantile haemangiomas: a retrospective multicentre study. Acta Derm Venereol. 96 (7): 963-966. https://doi.org/10.2340/00015555-2357; PMid:26832659
Wassef M, Blei F, Adams D et al. (2015). Vascular anomalies classification: recommendations from the International Society for the Study of Vascular Anomalies. Pediatrics. 136 (1): e203-e214. https://doi.org/10.1542/peds.2014-3673; PMid:26055853
Weber FC, Greene AK, Adams DM et al. (2017). Role of imaging in the diagnosis of parotid infantile hemangiomas. Int J Pediatr Otorhinolaryngol. 102: 61-66. https://doi.org/10.1016/j.ijporl.2017.08.035; PMid:29106877
Wedgeworth E, Glover M, Irvine AD et al. (2016). Propranolol in the treatment of infantile haemangiomas: lessons from the European propranolol in the treatment of complicated haemangiomas (PITCH) taskforce survey. Br J Dermatol. 174 (3): 594-601. https://doi.org/10.1111/bjd.14233; PMid:26473312
Witman PM, Wagner AM, Scherer K et al. (2006). Complications following pulsed dye laser treatment of superficial hemangiomas. Lasers Surg Med. 38 (2):116-123. https://doi.org/10.1002/lsm.20294; PMid:16493677
Wu HW, Wang X, Zhang L et al. (2018). Topical timolol vs oral propranolol for the treatment of superficial infantile hemangiomas. Front Oncol. 8: 605. https://doi.org/10.3389/fonc.2018.00605; PMid:30619747 PMCid:PMC6305365
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