Surgical complications of Henoch-Schönlein purpura in children

Authors

  • K.V. Lapshyn Communal Noncommercial Enterprise of Lviv Regional Council clinical Centre of children’s healthcare, Ukraine
  • A.A. Pereyaslov Danylo Halytsky Lviv National Medical University, Ukraine https://orcid.org/0000-0002-1225-0299
  • B.I. Hyzha Communal Noncommercial Enterprise of Lviv Regional Council clinical Centre of children’s healthcare, Ukraine
  • L.Y. Hyzha Danylo Halytsky Lviv National Medical University, Ukraine https://orcid.org/0000-0003-1916-9108
  • N.M. Opikan Danylo Halytsky Lviv National Medical University, Ukraine

DOI:

https://doi.org/10.15574/PS.2024.83.91

Keywords:

children, Henoch-Schönlein purpura, intussusception, “acute scrotum” syndrome

Abstract

Henoch-Schönlein purpura is the systemic pathology that affected the small vessels of the skin, gastrointestinal tract, kidneys, and joints. Typical clinical manifestation of Henoch-Schönlein purpura include palpable purpura, abdominal pain syndrome, arthralgia, renal involvement, and, in some children, externa genitalia involvement.

The aim of this study was to present the own experience in the management of three children with the surgical complications of Henoch-Schönlein purpura.

The own experience includes three children with Henoch-Schönlein purpura, particularly two children with ileum intussusception (both of 3 years old) and one patient of 4 years old with the syndrome “acute scrotum”.

Gastrointestinal involvement may appear in most of patients with Henoch-Schönlein purpura and intussusception is the most common complication, which require the urgent treatment. Appearance of typical palpable purpura followed the abdominal pain syndrome and ultrasonography is the main method of diagnostic in this group of patients. Ileum and ileocolic are the common types of intussusception in children with Henoch-Schönlein purpura. The main method of treatment in case of ileum intussusception is surgical reduction, while in case of ileocolic intussusception non-surgical reduction can be applied.

Besides the typical manifestation of Henoch-Schönlein purpura, in some children could be the scrotal involvement, which developing after appearance of palpable purpura, and rare caused by inflammation or torsion of testis or hydatid. It is believed that patients with Henoch-Schönlein purpura and scrotal involvement have more severe clinical course when compared with patients with abdominal manifestation, which agreed with our observation.

Conclusions. In children older than one year, with the abdominal pain, with or without bloody stools, and ultrasonographic signs of intussusception, it is necessary consider about possibility the presence of Henoch-Schönlein purpura in these patients.

In children with Henoch-Schönlein purpura despite the corticosteroids’ treatment, could be developed the syndrome of “acute scrotum”, which required emergent surgery.

The research was carried out in accordance with the principles of the Declaration of Helsinki. The research protocol was approved by the Local Ethics Committee of the institution mentioned in the work. Informed consent of the patients was obtained for the research.

No conflict of interests was declared by the authors.

References

Acar BÇ, Tekin ZE, Güngörer V et al. (2023). Intussusception as a rare manifestation of immunoglobulin A vasculitis: Risk factors and treatment. J Paediatr Child Health. 59(3): 505-511. https://doi.org/10.1111/jpc.16335; PMid:36692146

Buscatti IM, Abrão HM, Kozu K et al. (2018). Characterization of scrotal involvement in children and adolescents with IgA vasculitis. Adv Rheumatol. 58(1): 38. https://doi.org/10.1186/s42358-018-0039-3; PMid:30657092

Choong CK, Beasley SW. (1998). Intra-abdominal manifestations of Henoch-Schönlein Purpura. J Paediatr Child Health. 34(5): 405-409. https://doi.org/10.1046/j.1440-1754.1998.00263.x; PMid:9767498

Dedeoglu F, Sundel RP. (2005). Vasculitis in children. Pediatr Clin North Am. 52(2): 547-575. https://doi.org/10.1016/j.pcl.2005.01.006; PMid:15820379

Eleftheriou D, Brogan PA. (2017). Vasculitis in children. Paediatr Child Health. 28(2): 57-63. https://doi.org/10.1016/j.paed.2017.10.009

Güneş M, Kaya C, Koca O et al. (2012). Acute scrotum in Henoch-Schönlein purpura: Fact or fiction? Turk J Pediatr. 54(2): 194-197.

Guo H, Wang ZL, Tao Z. (2023) Delayed diagnosis of abdominal Henoch-Schonlein purpura in children: A case report. World J Clin Cases. 11(26): 6311-6317. https://doi.org/10.12998/wjcc.v11.i26.6311; PMid:37731573 PMCid:PMC10507560

Hara Y, Tajiri T, Matsuura K, Hasegawa A. (2004) Acute scrotum caused by Henoch-Schönlein purpura. Int J Urol. 11(7): 578-580. https://doi.org/10.1111/j.1442-2042.2004.00835.x; PMid:15242376

Hernstadt HM, Bartlett M, Kausman JY et al. (2015). Complicated Henoch-Schönlein purpura. J Paediatr Child Health. 51(6): 639-642. https://doi.org/10.1111/jpc.12786; PMid:25510813

Hu JJ, Zhao YW, Wen R et al. (2023). Immunoglobulin A vasculitis with testicular/epididymal involvement in children: A retrospective study of a ten-year period. Front Pediatr. 11: 1141118. https://doi.org/10.3389/fped.2023.1141118; PMid:37020657 PMCid:PMC10067670

Jangjoo A, Amouzeshi A, Jalali AN. (2008) Gangrenous appendicitis in a child with Henoch-Schonlein purpura. J Pediatr Surg. 43(11): e33-35. https://doi.org/10.1016/j.jpedsurg.2008.06.012; PMid:18970918

Jennette JC. (2013) Overview of the 2012 revised International Chapel Hill Consensus Conference nomenclature of vasculitides. Clin Exp Nephrol. 17(5):603-606. https://doi.org/10.1007/s10157-013-0869-6; PMid:24072416 PMCid:PMC4029362

Kamath N, Rao S. (2012). Henoch-Schonlein purpura: An update. Indian J Rheumatol. 7; Suppl 1: S92-S98. https://doi.org/10.1016/S0973-3698(12)60034-X

Kanik A, Kose E, Baran M et al. (2015). Henoch-Schönlein purpura in two pediatric patients presenting as terminal ileitis. Dig Dis Sci. 60(1): 269-271. https://doi.org/10.1007/s10620-014-3273-5; PMid:25052148

Katz S, Borst M, Seekri I, Grosfeld JL. (1991). Surgical evaluation of Henoch-Schönlein purpura. Experience with 110 children. Arch Surg. 126(7): 849-853. https://doi.org/10.1001/archsurg.1991.01410310059008; PMid:1854244

Lai HC. (2010). Henoch-Schönlein purpura with intussusception: a case report. Pediatr Neonatol. 51(1): 65-67. https://doi.org/10.1016/S1875-9572(10)60013-7; PMid:20225542

Lava SAG, Milani GP, Fossali EF et al. (2017). Cutaneous manifestations of small-vessel leukocytoclastic vasculitides in childhood. Clin Rev Allergy Immunol. 53(3): 439-451. https://doi.org/10.1007/s12016-017-8626-3; PMid:28836099

Liu C, Du LN, Zhao Q et al. (2024). Immunoglobulin A vasculitis with intussusception in children. Am Surg. 90(6):1298-1308. Epub 2024 Jan 24. https://doi.org/10.1177/00031348241229627; PMid:38264960

Ma Y, Zhang S, Chen J et al. (2021). Henoch-Schönlein purpura with scrotal involvement: A case report and literature review. J Pediatr Hematol Oncol. 43(6): 211-215. https://doi.org/10.1097/MPH.0000000000002161; PMid:33885039 PMCid:PMC8327932

Marsicovetere P, Ivatury SJ, White B, Holubar SD. (2017). Intestinal intussusception: Etiology, diagnosis, and treatment. Clin Colon Rectal Surg. 30(1): 30-39. https://doi.org/10.1055/s-0036-1593429; PMid:28144210 PMCid:PMC5179276

Martinez-Frontanilla LA, Silverman L, Meagher DP. (1988). Intussusception in Henoch-Schonlein purpura: Diagnosis with ultrasound. J Pediatr Surg. 23(4): 375-376. https://doi.org/10.1016/S0022-3468(88)80214-8; PMid:3290426

Montorfani-Janett VML, Montorfani GE, Lavagno C et al. (2022). External male genitalia in Henoch-Schönlein syndrome: A systematic review. Children (Basel). 9(8): 1154. https://doi.org/10.3390/children9081154; PMid:36010045 PMCid:PMC9406875

Mu J. (2024). Clinical characteristics and risk factors of IgA vasculitis with intussusception and intestinal perforation. J Paediatr Child Health. 60(1): 5-11. https://doi.org/10.1111/jpc.16516; PMid:37942803

Nicoara O, Twombley K. (2019). Immunoglobulin A nephropathy and immunoglobulin A vasculitis. Pediatr Clin N Am. 66(1): 101-110. https://doi.org/10.1016/j.pcl.2018.08.008; PMid:30454736

Ozen S, Pistorio A, Iusan SM et al. (2010). EULAR/PRINTO/PRES criteria for Henoch-Schönlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part II: Final classification criteria. Ann Rheum Dis. 69(5): 798-806. https://doi.org/10.1136/ard.2009.116657; PMid:20413568

Özkaya AK, Güler E, Çetinkaya A et al. (2016). Henoch-Schönlein purpura complicated by acalculous cholecystitis and intussusception, and following recurrence with appendicitis. Paediatr Int Child Health. 36(2): 157-159. https://doi.org/10.1080/20469047.2015.1109250; PMid:27077617

Palit A, Inamadar AC. (2009). Childhood cutaneous vasculitis: a comprehensive appraisal. Indian J Dermatol. 54(2):110-117. https://doi.org/10.4103/0019-5154.53179; PMid:20101304 PMCid:PMC2807148

Rohner K, Marlais M, Ahn YH et al. (2024). Outcome of immunosuppression in children with IgA vasculitis-related nephritis. Nephrol Dial Transplant. gfae009. Online ahead of print. https://doi.org/10.1093/ndt/gfae009; PMid:38211969

Schnabel A, Hedrich CM. (2019). Childhood vasculitis. Front Pediatr. 10; 6: 421. https://doi.org/10.3389/fped.2018.00421; PMid:30687686 PMCid:PMC6335362

Shimoyama T, Matsuda N, Kurobe M et al. (2019). Colonoscopic diagnosis and reduction of recurrent intussusception owing to Henoch- Schönlein purpura without purpura. Paediatr Int Child Health. 39(3): 219-223. https://doi.org/10.1080/20469047.2018.1457273; PMid:29621936

Sohagia AB, Gunturu SG, Tong TR, Hertan HI. (2010). Henoch-Schonlein purpura - a case report and review of the literature. Gastroenterol Res Pract. 2010: 597648. https://doi.org/10.1155/2010/597648; PMid:20508739 PMCid:PMC2874920

Sönmez K, Turkyilmaz Z, Demirogullari B et al. (2002). Conservative treatment for small intestinal intussusception associated with Henoch-Schönlein's purpura. Surg Today. 32(12): 1031-1034. https://doi.org/10.1007/s005950200209; PMid:12541018

Wei CH, Fu YW, Wang NL et al. (2015). Laparoscopy versus open surgery for idiopathic intussusception in children. Surg Endosc. 29(3): 668-672. https://doi.org/10.1007/s00464-014-3717-1; PMid:25037726

Zhan Y, Wu M, Li K et al. (2022). Development and validation of a differential diagnosis model for acute appendicitis and Henoch-Schonlein purpura in children. Pediatr Allergy Immunol Pulmonol. 35(2): 86-94. https://doi.org/10.1089/ped.2021.0218; PMid:35723658

Zhao Q, Yang Y, He SW et al. (2021). Risk factors for intussusception in children with Henoch-Schönlein purpura: A case-control study. World J Clin Cases. 9(22): 6244-6253. https://doi.org/10.12998/wjcc.v9.i22.6244; PMid:34434991 PMCid:PMC8362585

Published

2024-06-28